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<B>Alzheimer's Disease Transition Probabilities in the National Alzheimer's
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   Lead Investigator:    Urvi Desai
   Institution      :    Analysis Group, Inc.
   E-Mail           :    urvi.desai@analysisgroup.com
   Proposal ID      :    799
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   Publications:
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1  Kirson NY, Scott Andrews J, Desai U, King SB, Schonfeld S, Birnbaum HG, Ball DE, Kahle-Wrobleski K
   Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease
   Journal Article  J Alzheimers Dis,61:295-307,2018,PMC5734126
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>The project will have the following primary objectives:                           1. Describe characteristics of participants with mild AD                          2. Estimate the probabilities of transitioning from mild AD to moderate AD and    severe AD over time using the cognitive score domain                              3. Describe the living situation, functional outcomes, and medication use over    time, stratified by cognitive status at the time of evaluating the outcomes       In addition, the project has the following secondary objectives:                  1. Repeat primary analyses among cohort of participants with mild cognitive       impairment                                                                        2. Explore the feasibility of identifying a threshold for clinically meaningful   decline in cognition/functional capabilities </textarea>